Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Identifieur interne : 001912 ( Main/Exploration ); précédent : 001911; suivant : 001913Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Auteurs : Li Feng [République populaire de Chine] ; Xiaoyu Liu [République populaire de Chine] ; Weiliang Zhu [République populaire de Chine] ; Fujiang Guo [République populaire de Chine] ; Yingchun Wu [République populaire de Chine] ; Rui Wang [République populaire de Chine] ; Kaixian Chen [République populaire de Chine] ; Cheng Huang [République populaire de Chine] ; Yiming Li [République populaire de Chine]Source :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antienzymes (), Antienzymes (pharmacologie), Antienzymes (usage thérapeutique), Cinétique, Femelle, Glycine (), Glycine (analogues et dérivés), Glycine (pharmacologie), Glycine (usage thérapeutique), Humains, Leukocyte elastase (antagonistes et inhibiteurs), Leukocyte elastase (métabolisme), Modèles animaux de maladie humaine, Pneumopathie infectieuse (traitement médicamenteux), Saponines (pharmacologie), Saponines (usage thérapeutique), Simulation de docking moléculaire, Souris de lignée BALB C, Spectroscopie par résonance magnétique du proton, Sulfonamides (), Sulfonamides (pharmacologie), Sulfonamides (usage thérapeutique), Tabagisme (effets indésirables), Triterpènes (), Triterpènes (pharmacologie), Triterpènes (usage thérapeutique), Triterpènes pentacycliques (), Triterpènes pentacycliques (pharmacologie), Triterpènes pentacycliques (usage thérapeutique).
- MESH :
- analogues et dérivés : Glycine.
- antagonistes et inhibiteurs : Leukocyte elastase.
- effets indésirables : Tabagisme.
- métabolisme : Leukocyte elastase.
- pharmacologie : Antienzymes, Glycine, Saponines, Sulfonamides, Triterpènes, Triterpènes pentacycliques.
- traitement médicamenteux : Pneumopathie infectieuse.
- usage thérapeutique : Antienzymes, Glycine, Saponines, Sulfonamides, Triterpènes, Triterpènes pentacycliques.
- Animaux, Antienzymes, Cinétique, Femelle, Glycine, Humains, Modèles animaux de maladie humaine, Simulation de docking moléculaire, Souris de lignée BALB C, Spectroscopie par résonance magnétique du proton, Sulfonamides, Triterpènes, Triterpènes pentacycliques.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), Enzyme Inhibitors (therapeutic use), Female, Glycine (analogs & derivatives), Glycine (chemistry), Glycine (pharmacology), Glycine (therapeutic use), Humans, Kinetics, Leukocyte Elastase (antagonists & inhibitors), Leukocyte Elastase (metabolism), Mice, Inbred BALB C, Molecular Docking Simulation, Pentacyclic Triterpenes (chemistry), Pentacyclic Triterpenes (pharmacology), Pentacyclic Triterpenes (therapeutic use), Pneumonia (drug therapy), Proton Magnetic Resonance Spectroscopy, Saponins (pharmacology), Saponins (therapeutic use), Smoking (adverse effects), Sulfonamides (chemistry), Sulfonamides (pharmacology), Sulfonamides (therapeutic use), Triterpenes (chemistry), Triterpenes (pharmacology), Triterpenes (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Glycine.
- chemical , antagonists & inhibitors : Leukocyte Elastase.
- chemical , chemistry : Enzyme Inhibitors, Glycine, Pentacyclic Triterpenes, Sulfonamides, Triterpenes.
- chemical , metabolism : Leukocyte Elastase.
- chemical , pharmacology : Enzyme Inhibitors, Glycine, Pentacyclic Triterpenes, Saponins, Sulfonamides, Triterpenes.
- chemical , therapeutic use : Enzyme Inhibitors, Glycine, Pentacyclic Triterpenes, Saponins, Sulfonamides, Triterpenes.
- adverse effects : Smoking.
- drug therapy : Pneumonia.
- Animals, Disease Models, Animal, Female, Humans, Kinetics, Mice, Inbred BALB C, Molecular Docking Simulation, Proton Magnetic Resonance Spectroscopy.
Abstract
Inhibiting human neutrophil elastase (HNE) is a promising strategy for treating inflammatory lung diseases, such as H1N1 and SARS virus infections. The use of sivelestat, the only clinically registered synthesized HNE inhibitor, is largely limited by its risk of organ toxicity because it irreversibly inhibits HNE. Therefore, potent reversible HNE inhibitors are promising alternatives to sivelestat.
DOI: 10.1371/journal.pone.0082794
PubMed: 24376583
Affiliations:
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Le document en format XML
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xml:lang="en">Inhibition of human neutrophil elastase by pentacyclic triterpenes.</title><author><name sortKey="Feng, Li" sort="Feng, Li" uniqKey="Feng L" first="Li" last="Feng">Li Feng</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xiaoyu" sort="Liu, Xiaoyu" uniqKey="Liu X" first="Xiaoyu" last="Liu">Xiaoyu Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Chemistry, Second Military Medicinal University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biological Chemistry, Second Military Medicinal University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Weiliang" sort="Zhu, Weiliang" uniqKey="Zhu W" first="Weiliang" last="Zhu">Weiliang Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Fujiang" sort="Guo, Fujiang" uniqKey="Guo F" first="Fujiang" last="Guo">Fujiang Guo</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yingchun" sort="Wu, Yingchun" uniqKey="Wu Y" first="Yingchun" last="Wu">Yingchun Wu</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Rui" sort="Wang, Rui" uniqKey="Wang R" first="Rui" last="Wang">Rui Wang</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Kaixian" sort="Chen, Kaixian" uniqKey="Chen K" first="Kaixian" last="Chen">Kaixian Chen</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yiming" sort="Li, Yiming" uniqKey="Li Y" first="Yiming" last="Li">Yiming Li</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date 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(pharmacology)</term><term>Saponins (therapeutic use)</term><term>Smoking (adverse effects)</term><term>Sulfonamides (chemistry)</term><term>Sulfonamides (pharmacology)</term><term>Sulfonamides (therapeutic use)</term><term>Triterpenes (chemistry)</term><term>Triterpenes (pharmacology)</term><term>Triterpenes (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antienzymes ()</term><term>Antienzymes (pharmacologie)</term><term>Antienzymes (usage thérapeutique)</term><term>Cinétique</term><term>Femelle</term><term>Glycine ()</term><term>Glycine (analogues et dérivés)</term><term>Glycine (pharmacologie)</term><term>Glycine (usage thérapeutique)</term><term>Humains</term><term>Leukocyte elastase (antagonistes et inhibiteurs)</term><term>Leukocyte elastase (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Pneumopathie infectieuse (traitement médicamenteux)</term><term>Saponines (pharmacologie)</term><term>Saponines (usage thérapeutique)</term><term>Simulation de docking moléculaire</term><term>Souris de lignée BALB C</term><term>Spectroscopie par résonance magnétique du proton</term><term>Sulfonamides ()</term><term>Sulfonamides (pharmacologie)</term><term>Sulfonamides (usage thérapeutique)</term><term>Tabagisme (effets indésirables)</term><term>Triterpènes ()</term><term>Triterpènes (pharmacologie)</term><term>Triterpènes (usage thérapeutique)</term><term>Triterpènes pentacycliques ()</term><term>Triterpènes pentacycliques (pharmacologie)</term><term>Triterpènes pentacycliques (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Glycine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Leukocyte Elastase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Enzyme Inhibitors</term><term>Glycine</term><term>Pentacyclic Triterpenes</term><term>Sulfonamides</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Leukocyte Elastase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Enzyme Inhibitors</term><term>Glycine</term><term>Pentacyclic Triterpenes</term><term>Saponins</term><term>Sulfonamides</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Enzyme Inhibitors</term><term>Glycine</term><term>Pentacyclic Triterpenes</term><term>Saponins</term><term>Sulfonamides</term><term>Triterpenes</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Glycine</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Leukocyte elastase</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Leukocyte elastase</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antienzymes</term><term>Glycine</term><term>Saponines</term><term>Sulfonamides</term><term>Triterpènes</term><term>Triterpènes pentacycliques</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antienzymes</term><term>Glycine</term><term>Saponines</term><term>Sulfonamides</term><term>Triterpènes</term><term>Triterpènes pentacycliques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Kinetics</term><term>Mice, Inbred BALB C</term><term>Molecular Docking Simulation</term><term>Proton Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antienzymes</term><term>Cinétique</term><term>Femelle</term><term>Glycine</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Simulation de docking moléculaire</term><term>Souris de lignée BALB C</term><term>Spectroscopie par résonance magnétique du proton</term><term>Sulfonamides</term><term>Triterpènes</term><term>Triterpènes pentacycliques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inhibiting human neutrophil elastase (HNE) is a promising strategy for treating inflammatory lung diseases, such as H1N1 and SARS virus infections. The use of sivelestat, the only clinically registered synthesized HNE inhibitor, is largely limited by its risk of organ toxicity because it irreversibly inhibits HNE. Therefore, potent reversible HNE inhibitors are promising alternatives to sivelestat.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Feng, Li" sort="Feng, Li" uniqKey="Feng L" first="Li" last="Feng">Li Feng</name></noRegion><name sortKey="Chen, Kaixian" sort="Chen, Kaixian" uniqKey="Chen K" first="Kaixian" last="Chen">Kaixian Chen</name><name sortKey="Guo, Fujiang" sort="Guo, Fujiang" uniqKey="Guo F" first="Fujiang" last="Guo">Fujiang Guo</name><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name><name sortKey="Li, Yiming" sort="Li, Yiming" uniqKey="Li Y" first="Yiming" last="Li">Yiming Li</name><name sortKey="Liu, Xiaoyu" sort="Liu, Xiaoyu" uniqKey="Liu X" first="Xiaoyu" last="Liu">Xiaoyu Liu</name><name sortKey="Wang, Rui" sort="Wang, Rui" uniqKey="Wang R" first="Rui" last="Wang">Rui Wang</name><name sortKey="Wu, Yingchun" sort="Wu, Yingchun" uniqKey="Wu Y" first="Yingchun" last="Wu">Yingchun Wu</name><name sortKey="Zhu, Weiliang" sort="Zhu, Weiliang" uniqKey="Zhu W" first="Weiliang" last="Zhu">Weiliang Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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